I saw a demonstration at Kalamazoo where one layer of text was colored red (Photoshop, Gimp, etc.) while everything else (non-neutral) was colored blue. Then, looking at the image through standard red/blue 3D glasses, the palimpsest popped off the page. This is a poor man's version of multi-spectral imaging and it depends on the possibility of isolating one layer of ink by color, but it was surprising how well it worked!
Jesse